{"id":121,"date":"2012-11-05T11:35:44","date_gmt":"2012-11-05T15:35:44","guid":{"rendered":"https:\/\/sites.owu.edu\/wolverton\/?page_id=121"},"modified":"2016-12-01T08:50:42","modified_gmt":"2016-12-01T13:50:42","slug":"signal-transduction","status":"publish","type":"page","link":"https:\/\/sites.owu.edu\/wolverton\/teaching\/cell-bio\/signal-transduction\/","title":{"rendered":"Signal Transduction"},"content":{"rendered":"<p><!--:en--><\/p>\n<h2 id=\"links\">Links<\/h2>\n<p><a href=\"http:\/\/www.nature.com\/principles\/ebooks\/introduction-to-cell-biology-4570805\/4569830\">Principles Module 21<\/a><\/p>\n<h2 id=\"objectives\">Objectives<\/h2>\n<ul>\n<li>Describe the role of phosphorylation in signal transduction<\/li>\n<li>Discuss signal amplification<\/li>\n<li>Identify several second messenger molecules and their functions<\/li>\n<li>Describe some typical results of signal transduction in the cell<\/li>\n<\/ul>\n<h2 id=\"keypoints\">Key points<\/h2>\n<ul>\n<li>Many signal transduction chains employ protein phosphorylation\n<ul>\n<li>kinases are enzymes that attach a phosphate to a substrate<\/li>\n<li>phosphatases are enzymes that remove phosphates<\/li>\n<\/ul>\n<\/li>\n<li>Phosphorylation state changes the activity of a protein<\/li>\n<li>Second messengers connect receptors to kinase cascades<\/li>\n<li>Cells amplify signals through signal transduction cascades (Fig. 4)<\/li>\n<li>Signal transduction chains result in cellular responses\n<ul>\n<li>changes in gene expression<\/li>\n<li>changes in protein activity or degradation<\/li>\n<li>passage through the cell cycle and into cell division<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h2 id=\"in-classactivities\">In-class activities<\/h2>\n<ul>\n<li>Review for Friday\u2019s exam, ask any questions for clarification<\/li>\n<\/ul>\n<p><!--:--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Links Principles Module 21 Objectives Describe the role of phosphorylation in signal transduction Discuss signal amplification Identify several second messenger molecules and their functions Describe some typical results of signal transduction in the cell Key points Many signal transduction chains employ protein phosphorylation kinases are enzymes that attach a phosphate to a substrate phosphatases are [&hellip;]<\/p>\n","protected":false},"author":40,"featured_media":0,"parent":447,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-121","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/sites.owu.edu\/wolverton\/wp-json\/wp\/v2\/pages\/121","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.owu.edu\/wolverton\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.owu.edu\/wolverton\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.owu.edu\/wolverton\/wp-json\/wp\/v2\/users\/40"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.owu.edu\/wolverton\/wp-json\/wp\/v2\/comments?post=121"}],"version-history":[{"count":1,"href":"https:\/\/sites.owu.edu\/wolverton\/wp-json\/wp\/v2\/pages\/121\/revisions"}],"predecessor-version":[{"id":517,"href":"https:\/\/sites.owu.edu\/wolverton\/wp-json\/wp\/v2\/pages\/121\/revisions\/517"}],"up":[{"embeddable":true,"href":"https:\/\/sites.owu.edu\/wolverton\/wp-json\/wp\/v2\/pages\/447"}],"wp:attachment":[{"href":"https:\/\/sites.owu.edu\/wolverton\/wp-json\/wp\/v2\/media?parent=121"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}