{"id":118,"date":"2012-11-05T11:35:13","date_gmt":"2012-11-05T15:35:13","guid":{"rendered":"https:\/\/sites.owu.edu\/wolverton\/?page_id=118"},"modified":"2016-12-01T08:50:41","modified_gmt":"2016-12-01T13:50:41","slug":"cell-signaling","status":"publish","type":"page","link":"https:\/\/sites.owu.edu\/wolverton\/teaching\/cell-bio\/cell-signaling\/","title":{"rendered":"Cell Signaling"},"content":{"rendered":"<p><!--:en--><\/p>\n<h2 id=\"links\">Links<\/h2>\n<p><a href=\"http:\/\/www.nature.com\/principles\/ebooks\/introduction-to-cell-biology-4570805\/4569825\/1\">Principles Module 20<\/a><\/p>\n<h2 id=\"objectives\">Objectives<\/h2>\n<ul>\n<li>Be able to describe the types of cell signaling<\/li>\n<li>Be able to predict the receptor type based on the ligand<\/li>\n<li>Be able to discuss the results of cell signaling<\/li>\n<\/ul>\n<h2 id=\"keypoints\">Key points<\/h2>\n<ul>\n<li>Signaling involves the interaction of a ligand with a receptor\n<ul>\n<li>ligands are molecules that induce a sensory cell to respond<\/li>\n<li>receptors are specific to a particular ligand and initiate signal transduction<\/li>\n<\/ul>\n<\/li>\n<li>Signal types are classified based on signaling distance\n<ul>\n<li>autocrine signals target receptors in same cell<\/li>\n<li>paracrine signaling targets cells near the originating cell<\/li>\n<li>endocrine signals travel through the circulatory system<\/li>\n<\/ul>\n<\/li>\n<li>some signals travel between adjacent cells via gap junctions, synapses<\/li>\n<li>location of receptors depends on properties of ligand\n<ul>\n<li>transmembrane receptors bind to ligand outside cell\n<ul>\n<li>ion channel-linked, protein kinase, G protein-coupled receptors<\/li>\n<\/ul>\n<\/li>\n<li>cytoplasmic \/ nuclear receptors bind to ligand inside cell\n<ul>\n<li>steroid hormone receptors<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<li>reception \u2192 transduction \u2192 response<\/li>\n<li>example responses: enzyme activation, gene expression, physiological change<\/li>\n<\/ul>\n<h2 id=\"in-classactivities\">In-class activities<\/h2>\n<ul>\n<li>Read the paper bundle <a href=\"http:\/\/www.nature.com\/principles\/content\/ne0000\/ne0000\/ne0000\/ne0000\/1256387\/PLS_AnimSystem_nchembio.552.pdf#toolbar=0\"><em>Innovation in Cannabis Medicine<\/em><\/a>and respond to the following questions:\n<ul>\n<li>What is the biologiacl basis for the researchers to believe that THC effects on the brain could be separate from its effects on pain?<\/li>\n<li>What kind of receptor is the glycine receptor? What kind is the CB1R?<\/li>\n<li>Why did the researchers modify the glycine receptor, and what did they conclude?<\/li>\n<li>Why did the researchers modify the THC molecule, and what did they conclude from these experiments?<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p><!--:--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Links Principles Module 20 Objectives Be able to describe the types of cell signaling Be able to predict the receptor type based on the ligand Be able to discuss the results of cell signaling Key points Signaling involves the interaction of a ligand with a receptor ligands are molecules that induce a sensory cell to [&hellip;]<\/p>\n","protected":false},"author":40,"featured_media":0,"parent":447,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-118","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/sites.owu.edu\/wolverton\/wp-json\/wp\/v2\/pages\/118","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.owu.edu\/wolverton\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.owu.edu\/wolverton\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.owu.edu\/wolverton\/wp-json\/wp\/v2\/users\/40"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.owu.edu\/wolverton\/wp-json\/wp\/v2\/comments?post=118"}],"version-history":[{"count":1,"href":"https:\/\/sites.owu.edu\/wolverton\/wp-json\/wp\/v2\/pages\/118\/revisions"}],"predecessor-version":[{"id":494,"href":"https:\/\/sites.owu.edu\/wolverton\/wp-json\/wp\/v2\/pages\/118\/revisions\/494"}],"up":[{"embeddable":true,"href":"https:\/\/sites.owu.edu\/wolverton\/wp-json\/wp\/v2\/pages\/447"}],"wp:attachment":[{"href":"https:\/\/sites.owu.edu\/wolverton\/wp-json\/wp\/v2\/media?parent=118"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}